BAIT
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNA2
DNA2L, hDNA2, RP11-9E13.1
DNA replication helicase/nuclease 2
GO Process (17)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing [IDA]
- DNA duplex unwinding [IDA]
- DNA replication [IMP]
- DNA replication checkpoint [IMP]
- DNA replication, Okazaki fragment processing [IDA]
- DNA replication, removal of RNA primer [IDA]
- DNA strand elongation involved in DNA replication [TAS]
- base-excision repair [IDA]
- mitochondrial DNA repair [IDA]
- mitochondrial DNA replication [IDA]
- mitotic cell cycle [TAS]
- positive regulation of DNA replication [IDA]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
Gene Ontology Molecular Function- 5'-3' DNA helicase activity [IDA]
- 5'-flap endonuclease activity [IDA]
- ATPase activity [TAS]
- DNA binding [IDA]
- DNA helicase activity [IDA]
- helicase activity [TAS]
- nuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA-dependent ATPase activity [IDA]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- 5'-3' DNA helicase activity [IDA]
- 5'-flap endonuclease activity [IDA]
- ATPase activity [TAS]
- DNA binding [IDA]
- DNA helicase activity [IDA]
- helicase activity [TAS]
- nuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA-dependent ATPase activity [IDA]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-?9). Surprisingly, while CUL3-?9 is hyperneddylated, a post-translational modification that typically activates CRL ... [more]
Int J Mol Sci May. 05, 2022; 23(9); [Pubmed: 35563538]
Throughput
- High Throughput
Curated By
- BioGRID