BAIT
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GAS6
AXLLG, AXSF
growth arrest-specific 6
GO Process (66)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- B cell chemotaxis [IDA]
- activation of protein kinase B activity [ISS]
- apoptotic cell clearance [IDA]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [TAS]
- cell cycle arrest [TAS]
- cell migration [TAS]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to interferon-alpha [IDA]
- cellular response to vitamin K [IDA]
- dendritic cell differentiation [IEP]
- extracellular matrix assembly [ISS]
- fusion of virus membrane with host plasma membrane [IDA]
- hematopoietic stem cell migration to bone marrow [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of biomineral tissue development [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-6 secretion [IDA]
- negative regulation of oligodendrocyte apoptotic process [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of renal albumin absorption [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- peptidyl-serine phosphorylation [IDA]
- phagocytosis [IDA]
- platelet activation [TAS]
- platelet aggregation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of TOR signaling [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of dendritic cell chemotaxis [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of natural killer cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of protein export from nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of protein tyrosine kinase activity [IDA]
- post-translational protein modification [TAS]
- protein kinase B signaling [IDA]
- protein phosphorylation [IDA]
- protein targeting to plasma membrane [IDA]
- proteolysis [TAS]
- receptor-mediated virion attachment to host cell [IDA]
- signal transduction [IDA, TAS]
- viral entry into host cell [IDA]
- viral genome replication [IDA]
Gene Ontology Molecular Function- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-?9). Surprisingly, while CUL3-?9 is hyperneddylated, a post-translational modification that typically activates CRL ... [more]
Int J Mol Sci May. 05, 2022; 23(9); [Pubmed: 35563538]
Throughput
- High Throughput
Curated By
- BioGRID