BAIT
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TNFRSF11A
CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
GO Process (18)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- TNFSF11-mediated signaling pathway [IMP]
- adaptive immune response [IMP]
- cell-cell signaling [TAS]
- circadian temperature homeostasis [ISS]
- monocyte chemotaxis [NAS]
- osteoclast differentiation [IMP]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [IMP]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA, IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISS]
- response to cytokine [IMP]
- response to interleukin-1 [ISS]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [ISS]
- signal transduction [TAS]
- tumor necrosis factor-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling.
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-?9). Surprisingly, while CUL3-?9 is hyperneddylated, a post-translational modification that typically activates CRL ... [more]
Int J Mol Sci May. 05, 2022; 23(9); [Pubmed: 35563538]
Throughput
- High Throughput
Curated By
- BioGRID