BAIT
ZMYM2
FIM, MYM, RAMP, SCLL, ZNF198, RP11-264J4.7
zinc finger, MYM-type 2
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Homo sapiens
PREY
TUBA1B
K-ALPHA-1
tubulin, alpha 1b
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.
Histone modifications in chromatin regulate gene expression. A transcriptional co-repressor complex containing LSD1-CoREST-HDAC1 (termed LCH hereafter for simplicity) represses transcription by coordinately removing histone modifications associated with transcriptional activation. RE1-silencing transcription factor (REST) recruits LCH to the promoters of neuron-specific genes, thereby silencing their transcription in non-neuronal tissues. ZNF198 is a member of a family of MYM-type zinc finger proteins ... [more]
PLoS ONE Sep. 23, 2008; 3(9);e3255 [Pubmed: 18806873]
Throughput
- Low Throughput
Curated By
- BioGRID