BAIT
INPP5K
PPS, SKIP
inositol polyphosphate-5-phosphatase K
GO Process (37)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- actin cytoskeleton organization [NAS]
- cellular response to cAMP [ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to hormone stimulus [ISS]
- cellular response to insulin stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- dephosphorylation [IDA, IMP]
- glucose homeostasis [ISS]
- inositol phosphate dephosphorylation [IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of calcium ion transport [IDA]
- negative regulation of dephosphorylation [ISS]
- negative regulation of glucose transport [IDA]
- negative regulation of glycogen (starch) synthase activity [ISS]
- negative regulation of glycogen biosynthetic process [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-threonine phosphorylation [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein targeting to membrane [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of stress fiber assembly [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA]
- phospholipid metabolic process [TAS]
- positive regulation of renal water transport [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of urine volume [ISS]
- protein targeting to plasma membrane [ISS]
- regulation of glycogen biosynthetic process [ISS]
- ruffle assembly [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
ASPM
ASP, Calmbp1, MCPH5, RP11-32D17.1
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Combinatorial CRISPR screen identifies fitness effects of gene paralogues.
Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1191 gene pairs, including paralogues and known and predicted synthetic lethal interactions to identify 105 gene combinations whose ... [more]
Nat Commun Dec. 26, 2020; 12(1);1302 [Pubmed: 33637726]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [viability (PATO:0000169)]
Additional Notes
- CRISPR GI screen
- Cell Line: MEWO cell BTO:0003301
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative genetic interaction
- Library: Targeted CRISPR synthetic lethality library
- Significance Threshold:FDR<0.1 and additional filtering of gene pairs with one gene with a large individual fitness defect
Curated By
- BioGRID