BAIT
CDH1
HCT1, L000004229, YGL003C
Activator of anaphase-promoting complex/cyclosome (APC/C); cell-cycle regulated; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- positive regulation of cyclin catabolic process [IDA]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of cell size [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
CLN1
cyclin CLN1, L000000357, YMR199W
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Positive feedback of G1 cyclins ensures coherent cell cycle entry.
In budding yeast, Saccharomyces cerevisiae, the Start checkpoint integrates multiple internal and external signals into an all-or-none decision to enter the cell cycle. Here we show that Start behaves like a switch due to systems-level feedback in the regulatory network. In contrast to current models proposing a linear cascade of Start activation, transcriptional positive feedback of the G1 cyclins Cln1 ... [more]
Nature Jul. 17, 2008; 454(7202);291-6 [Pubmed: 18633409]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression through the g1/s phase transition (APO:0000269)
Additional Notes
- mutation of CDH1 can partially rescue the G1 arrest seen in CLN1/CLN2 double mutants
Related interactions
Curated By
- BioGRID