KR
Gene Ontology Biological Process
- Malpighian tubule bud morphogenesis [IGI]
- Malpighian tubule morphogenesis [NAS, TAS]
- axon guidance [IMP]
- chromatin silencing [IMP]
- compound eye development [IMP]
- ganglion mother cell fate determination [TAS]
- muscle organ development [TAS]
- negative regulation of gene expression [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- negative regulation of transcription, DNA-templated [IDA]
- neuroblast fate determination [IEP, IMP]
- regulation of development, heterochronic [NAS, TAS]
- regulation of hemocyte proliferation [IMP]
- trunk segmentation [TAS]
- ventral cord development [NAS]
- wing disc development [IGI]
- zygotic determination of anterior/posterior axis, embryo [NAS, TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [NAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [NAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
CTBP
Gene Ontology Biological Process
- Wnt signaling pathway [IGI]
- chaeta development [IMP]
- embryonic development via the syncytial blastoderm [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of JAK-STAT cascade [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IMP]
- sensory organ precursor cell fate determination [IMP]
- wing disc development [IMP]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein interaction map of Drosophila melanogaster.
Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20,405 interactions. A computational method of rating two-hybrid interaction confidence ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KR CTBP | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID