BAIT
PAFAH1B1
LIS1, LIS2, MDCR, MDS, PAFAH
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
GO Process (24)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- acrosome assembly [ISS]
- actin cytoskeleton organization [ISS]
- adult locomotory behavior [IMP]
- brain morphogenesis [IMP]
- cerebral cortex development [IMP]
- corpus callosum morphogenesis [IMP]
- establishment of mitotic spindle orientation [IMP]
- hippocampus development [ISS]
- layer formation in cerebral cortex [ISS]
- learning or memory [ISS]
- microtubule cytoskeleton organization [ISS]
- microtubule organizing center organization [IMP]
- microtubule-based process [IDA]
- mitotic cell cycle [TAS]
- neuroblast proliferation [ISS]
- neuromuscular process controlling balance [IMP]
- neuron migration [IMP, ISS]
- platelet activating factor metabolic process [ISS]
- regulation of Rho GTPase activity [ISS]
- retrograde axon cargo transport [ISS]
- synaptic transmission [ISS]
- transmission of nerve impulse [ISS]
- vesicle transport along microtubule [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FNTA
FPTA, PGGT1A, PTAR2
farnesyltransferase, CAAX box, alpha
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- phototransduction, visible light [TAS]
- positive regulation of deacetylase activity [IDA]
- positive regulation of tubulin deacetylation [IDA]
- protein farnesylation [IDA]
- protein geranylgeranylation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- rhodopsin mediated signaling pathway [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF7 cell line (score 0.655)
- MDA231 cell line (score 0.654)
Curated By
- BioGRID