PARK2
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- aggresome assembly [ISO]
- cellular protein catabolic process [ISO]
- cellular response to toxic substance [ISO]
- dopamine metabolic process [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- learning [IMP]
- locomotory behavior [IMP]
- mitochondrion degradation [ISO]
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of cell death [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of glucokinase activity [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of oxidative stress-induced neuron death [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- norepinephrine metabolic process [IMP]
- positive regulation of DNA binding [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of mitochondrial fusion [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein linear polyubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein metabolic process [IMP]
- protein monoubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of autophagy [ISO]
- regulation of mitochondrion organization [ISO]
- regulation of neurotransmitter secretion [IMP]
- regulation of reactive oxygen species metabolic process [ISO]
- regulation of synaptic transmission [IMP]
- response to endoplasmic reticulum stress [ISO]
- response to unfolded protein [ISO]
- startle response [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- F-box domain binding [ISO]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- PDZ domain binding [ISO]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- tubulin binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-specific protease binding [ISO]
- F-box domain binding [ISO]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- PDZ domain binding [ISO]
- actin binding [ISO]
- chaperone binding [ISO]
- cullin family protein binding [ISO]
- heat shock protein binding [ISO]
- histone deacetylase binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- tubulin binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- Golgi membrane [ISO]
- LUBAC complex [ISO]
- Parkin-FBXW7-Cul1 ubiquitin ligase complex [ISO]
- aggresome [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- intracellular [ISO]
- membrane raft [ISO]
- mitochondrion [ISO]
- neuron projection [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
- protein complex [IDA]
- synapse [ISO]
- synaptic vesicle [ISO]
- ubiquitin ligase complex [ISO]
NLRP3
Gene Ontology Biological Process
- NLRP3 inflammasome complex assembly [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cellular response to lipopolysaccharide [ISO]
- defense response to virus [IMP]
- inflammatory response [ISO]
- interleukin-1 beta production [IMP]
- interleukin-1 secretion [IMP]
- interleukin-18 production [IMP]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of acute inflammatory response [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of interleukin-1 beta secretion [IGI, ISO]
- regulation of inflammatory response [IMP]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Parkinson's disease (PD) is mediated, in part, by intraneuronal accumulation of ?-synuclein aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc). Microglial hyperactivation of the NOD-like receptor protein 3 (NLRP3) inflammasome has been well-documented in various neurodegenerative diseases, including PD. We show here that loss of parkin activity in mouse and human DA neurons results ... [more]
Throughput
- Low Throughput
Additional Notes
- E1:UBE1 E2:UbcH7
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK2 NLRP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID