CTBP1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- negative regulation of cell proliferation [TAS]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of histone deacetylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell cycle [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KLF4
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IDA]
- cellular response to laminar fluid shear stress [IMP]
- fat cell differentiation [ISS]
- mesodermal cell fate determination [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [TAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein metabolic process [IGI]
- positive regulation of telomerase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISS]
- positive regulation of transcription, DNA-templated [ISS, NAS]
- post-embryonic hemopoiesis [IMP]
- regulation of cell differentiation [ISS]
- stem cell maintenance [ISS]
- transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI, ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- sequence-specific DNA binding transcription factor recruiting transcription factor activity [ISS]
- transcription regulatory region DNA binding [ISS]
- zinc ion binding [NAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.
ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcription factor that binds both the progenitor and differentiation genes that it controls at a CCNNAGGC DNA motif. ZNF750 interacts with ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KLF4 CTBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CTBP1 KLF4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID