BAIT

TRK2

RPD2, L000002335, YKR050W

Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication

GO Process (2)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

cellular potassium ion homeostasis [IDA]

regulation of membrane potential [IMP]

Gene Ontology Molecular Function

potassium ion transmembrane transporter activity [IDA, ISS]

Gene Ontology Cellular Component

integral component of membrane [ISM]

plasma membrane [TAS]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

TRK1

L000002334, YJL129C

Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication

GO Process (1)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

cellular potassium ion homeostasis [IDA]

Gene Ontology Molecular Function

potassium ion transmembrane transporter activity [IDA]

Gene Ontology Cellular Component

integral component of membrane [ISM]

membrane raft [IDA]

plasma membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Exposing the fitness contribution of duplicated genes.

DeLuna A, Vetsigian K, Shoresh N, Hegreness M, Colon-Gonzalez M, Chao S, Kishony R

Duplicate genes from the whole-genome duplication (WGD) in yeast are often dispensable--removing one copy has little or no phenotypic consequence. It is unknown, however, whether such dispensability reflects insignificance of the ancestral function or compensation from paralogs. Here, using precise competition-based measurements of the fitness cost of single and double deletions, we estimate the exposed fitness contribution of WGD duplicate ... [more]

Nat. Genet. May. 01, 2008; 40(5);676-81 [Pubmed: 18408719]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TRK2 TRK1	Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.	Ko CH (1990)	Low	-	BioGRID	155815
TRK1 TRK2	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Costanzo M (2016)	High	-0.7979	BioGRID	2136822
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Anderson JA (1994)	Low	-	BioGRID	161805
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Bertl A (1994)	Low	-	BioGRID	161802
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Draexl S (2013)	Low	-	BioGRID	875259
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Fairman C (1999)	Low	-	BioGRID	156884
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ko CH (1990)	Low	-	BioGRID	156888
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ko CH (1991)	Low	-	BioGRID	156889
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Lapathitis G (1998)	Low	-	BioGRID	161569
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Madrid R (1998)	Low	-	BioGRID	156885
TRK1 TRK2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Wright MB (1997)	Low	-	BioGRID	156887
TRK1 TRK2	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Gonzalez A (2013)	Low	-	BioGRID	844875
TRK2 TRK1	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Ramos J (1994)	Low	-	BioGRID	161803
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	de Nadal E (1999)	Low	-	BioGRID	427673
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Erez O (2002)	Low	-	BioGRID	157443
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Gerber S (2010)	Low	-	BioGRID	429656
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Herrero L (2012)	Low	-	BioGRID	795817
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Liang H (1998)	Low	-	BioGRID	520367
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Maresova L (2005)	Low	-	BioGRID	164485
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Navarrete C (2010)	Low	-	BioGRID	442319
TRK2 TRK1	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Portillo F (2005)	Low	-	BioGRID	429794
TRK1 TRK2	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Ramos J (1994)	Low	-	BioGRID	161804
TRK1 TRK2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Bertl A (2003)	Low	-	BioGRID	159045
TRK1 TRK2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Erez O (2002)	Low	-	BioGRID	159046
TRK1 TRK2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Grishin A (2006)	Low	-	BioGRID	202319
TRK1 TRK2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Michel B (2006)	Low	-	BioGRID	202363
TRK1 TRK2	Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.	Vidal M (1990)	Low	-	BioGRID	159938

Curated By

BioGRID

Interaction Summary

TRK2

Gene Ontology Biological Process

Gene Ontology Molecular Function

potassium ion transmembrane transporter activity [IDA, ISS]

Gene Ontology Cellular Component

TRK1

Gene Ontology Biological Process

Gene Ontology Molecular Function

potassium ion transmembrane transporter activity [IDA]

Gene Ontology Cellular Component

Synthetic Growth Defect

Publication

Exposing the fitness contribution of duplicated genes.

Throughput

Ontology Terms

Related interactions

Curated By