MT3
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- activation of protein kinase B activity [IDA]
- astrocyte development [ISS]
- cadmium ion homeostasis [IDA]
- cell proliferation [TAS]
- cellular lipid catabolic process [ISS]
- cellular metal ion homeostasis [NAS, TAS]
- cellular response to cadmium ion [IDA]
- cellular response to drug [IDA]
- cellular response to hypoxia [IEP]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IEP]
- cellular zinc ion homeostasis [ISS]
- cholesterol catabolic process [ISS]
- energy reserve metabolic process [ISS]
- histone modification [IMP]
- leptin-mediated signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [ISS]
- negative regulation of axon extension [IDA]
- negative regulation of cell growth [IDA, IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of necrotic cell death [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of cell death [IDA, ISS]
- positive regulation of gene expression [IDA, ISS]
- positive regulation of lysosomal membrane permeability [ISS]
- positive regulation of necrotic cell death [IDA]
- positive regulation of oxygen metabolic process [ISS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IDA]
- protein stabilization [IDA]
- regulation of protein glycosylation [ISS]
- regulation of response to food [ISS]
- removal of superoxide radicals [IDA]
- response to hypoxia [IDA]
- zinc ion homeostasis [IDA]
- zinc ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYH9
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin cytoskeleton reorganization [IMP]
- actin filament-based movement [IDA]
- actomyosin structure organization [IDA]
- angiogenesis [IDA]
- axon guidance [TAS]
- blood vessel endothelial cell migration [IMP]
- cytokinesis [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [NAS]
- membrane protein ectodomain proteolysis [IDA]
- monocyte differentiation [IEP]
- platelet aggregation [IMP]
- platelet formation [IMP]
- protein transport [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- actin cytoskeleton [IDA]
- actomyosin [IDA]
- actomyosin contractile ring [IDA]
- cell leading edge [IDA]
- cleavage furrow [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integrin complex [IDA]
- membrane [IDA]
- myosin II complex [IDA]
- myosin II filament [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- ruffle [IDA]
- stress fiber [IDA]
- uropod [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.
Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells. MT-3 is expressed by epithelial cells of the human kidney, including the cells of the proximal tubule. Our laboratory has previously shown that mortal cultures of human proximal ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MT3 MYH9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID