BAIT
BIN1
AMPH2, AMPHL, SH3P9
bridging integrator 1
GO Process (6)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDK1
pyruvate dehydrogenase kinase, isozyme 1
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cellular metabolic process [TAS]
- hypoxia-inducible factor-1alpha signaling pathway [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- protein phosphorylation [IDA, IMP]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [TAS]
- regulation of glucose metabolic process [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1.
circRNA has been established to play a pivotal role in tumorigenesis development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of hypoxia-induced exosomal circRNAs in pancreatic cancer remain largely unknown.Differentially expressed circRNAs in exosomes between hypoxic exosomes and normoxic exosomes in PC cells were verified by RNA sequencing. The expression of circPDK1 in PC tumors and ... [more]
J Hematol Oncol Dec. 06, 2021; 15(1);128 [Pubmed: 36068586]
Throughput
- Low Throughput
Additional Notes
- Hit is circPDK1
Related interactions
Curated By
- BioGRID