BAIT
IRAK2
IRAK-2
interleukin-1 receptor-associated kinase 2
GO Process (26)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- interleukin-1-mediated signaling pathway [IMP]
- intracellular signal transduction [IBA]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP, TAS]
- regulation of cytokine-mediated signaling pathway [IMP]
- response to interleukin-1 [IMP]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ELANE
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
elastase, neutrophil expressed
GO Process (16)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [NAS]
- collagen catabolic process [TAS]
- defense response to bacterium [IDA]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of chemokine biosynthetic process [IDA]
- negative regulation of chemotaxis [NAS]
- negative regulation of inflammatory response [NAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of MAP kinase activity [NAS]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- protein catabolic process [NAS]
- proteolysis [IDA]
- response to UV [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 68.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID