BAIT
DAPK3
DLK, ZIP, ZIPK
death-associated protein kinase 3
GO Process (18)
GO Function (8)
GO Component (1)
Gene Ontology Biological Process
- apoptotic process [IDA, IMP]
- cellular response to interferon-gamma [IDA]
- cytokinesis [TAS]
- intracellular signal transduction [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- protein autophosphorylation [IDA, TAS]
- protein phosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [IDA, TAS]
- regulation of apoptotic process [IBA, TAS]
- regulation of autophagy [TAS]
- regulation of cell motility [TAS]
- regulation of focal adhesion assembly [IDA]
- regulation of mitosis [TAS]
- regulation of mitotic cell cycle [IMP]
- regulation of smooth muscle contraction [TAS]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
OPA1
MGM1, NPG, NTG, largeG
optic atrophy 1 (autosomal dominant)
GO Process (11)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- axon transport of mitochondrion [TAS]
- cellular senescence [IDA]
- inner mitochondrial membrane organization [IDA]
- mitochondrial fission [TAS]
- mitochondrial fusion [IDA, IMP, TAS]
- mitochondrial genome maintenance [IMP]
- mitochondrion organization [IMP, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 1156.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID