BAIT
PRKCG
PKC-gamma, PKCC, PKCG, SCA14
protein kinase C, gamma
GO Process (20)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of proteasomal protein catabolic process [ISS]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein ubiquitination [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of mismatch repair [IDA]
- protein phosphorylation [TAS]
- regulation of circadian rhythm [ISS]
- regulation of response to food [ISS]
- response to morphine [ISS]
- response to pain [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNAJC10
ERdj5, JPDI, MTHr, PDIA19, UNQ495/PRO1012
DnaJ (Hsp40) homolog, subfamily C, member 10
GO Process (6)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of protein phosphorylation [IDA]
- positive regulation of ATPase activity [ISS]
- protein folding in endoplasmic reticulum [IDA]
- response to endoplasmic reticulum stress [IDA]
Gene Ontology Molecular Function- ATPase activator activity [ISS]
- ATPase binding [IPI]
- Hsp70 protein binding [IPI]
- chaperone binding [IDA]
- disulfide oxidoreductase activity [ISS]
- misfolded protein binding [IDA]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [ISS]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISS]
- ATPase activator activity [ISS]
- ATPase binding [IPI]
- Hsp70 protein binding [IPI]
- chaperone binding [IDA]
- disulfide oxidoreductase activity [ISS]
- misfolded protein binding [IDA]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [ISS]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 68.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID