BAIT
PIM1
PIM
Pim-1 proto-oncogene, serine/threonine kinase
GO Process (8)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- cell proliferation [IDA]
- multicellular organismal development [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- protein autophosphorylation [IDA, IMP]
- protein phosphorylation [IDA]
- regulation of mitotic cell cycle [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
ENO2
HEL-S-279, NSE
enolase 2 (gamma, neuronal)
GO Process (5)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 68.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID