A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Multiple knockout analysis of genetic robustness in the yeast metabolic network.

Deutscher D, Meilijson I, Kupiec M, Ruppin E

Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that ... [more]

Nat. Genet. Sep. 01, 2006; 38(9);993-8 [Pubmed: 16941010]

Throughput

High Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

CTA1/CTT1/GLR1/PyrD quadruple mutant is synthetic lethal in synthetic rich media
genetic complex

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CTA1 CTT1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Bayliak M (2006)	Low	-	BioGRID	445471

Curated By

BioGRID

Interaction Summary

CTA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

catalase activity [IDA, IGI, IMP]

Gene Ontology Cellular Component

CTT1