BAIT
SER1
ADE9, O-phospho-L-serine:2-oxoglutarate transaminase, L000001865, YOR184W
3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
THR1
homoserine kinase, L000002298, YHR025W
Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway
GO Process (4)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Multiple knockout analysis of genetic robustness in the yeast metabolic network.
Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that ... [more]
Nat. Genet. Sep. 01, 2006; 38(9);993-8 [Pubmed: 16941010]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- SER1/THR1/YDR111C mutants are synthetic lethal in minimal media
- genetic complex
Curated By
- BioGRID