BAIT
MAP3K10
MEKK10, MLK2, MST
mitogen-activated protein kinase kinase kinase 10
GO Process (13)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- JNK cascade [TAS]
- activation of JNKK activity [ISS]
- activation of JUN kinase activity [ISS]
- apoptotic process [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IMP]
- protein autophosphorylation [ISS]
- signal transduction [TAS]
- smoothened signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
NDUFA8
CI-19KD, CI-PGIV, PGIV
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
GO Process (4)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 918.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID