BAIT
MAPK7
BMK1, ERK4, ERK5, PRKM7
mitogen-activated protein kinase 7
GO Process (32)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cAMP-mediated signaling [NAS]
- cellular response to growth factor stimulus [IGI]
- cellular response to hydrogen peroxide [IMP]
- cellular response to laminar fluid shear stress [IMP, TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- innate immune response [TAS]
- negative regulation of cAMP catabolic process [NAS]
- negative regulation of cyclic-nucleotide phosphodiesterase activity [NAS]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- negative regulation of heterotypic cell-cell adhesion [IGI]
- negative regulation of inflammatory response [TAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of response to cytokine stimulus [IGI]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein metabolic process [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
- signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
FLII
FLI, FLIL, Fli1
flightless I homolog (Drosophila)
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 136.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID