BAIT
CAMK2B
CAM2, CAMK2, CAMKB
calcium/calmodulin-dependent protein kinase II beta
GO Process (14)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of synapse maturation [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of calcium ion transport [TAS]
- regulation of dendritic spine development [TAS]
- regulation of long-term neuronal synaptic plasticity [TAS]
- regulation of skeletal muscle adaptation [TAS]
- regulation of synapse structural plasticity [TAS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITPR3
IP3R, IP3R3
inositol 1,4,5-trisphosphate receptor, type 3
GO Process (20)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G-protein coupled receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport into cytosol [ISS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [IDA, ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- protein heterooligomerization [ISS]
- protein homooligomerization [ISS]
- regulation of insulin secretion [TAS]
- response to calcium ion [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISS]
- brush border [ISS]
- cytoplasm [ISS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [IDA, ISS, TAS]
- integral component of plasma membrane [IDA]
- membrane [IDA]
- myelin sheath [ISS]
- neuronal cell body [ISS]
- nuclear outer membrane [ISS]
- plasma membrane [IDA]
- platelet dense tubular network membrane [TAS]
- receptor complex [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 510.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID