BAIT
PTK2B
CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
protein tyrosine kinase 2 beta
GO Process (53)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- activation of Janus kinase activity [IMP]
- angiogenesis [IBA]
- apoptotic process [TAS]
- bone resorption [ISS]
- cell surface receptor signaling pathway [IMP]
- cellular defense response [ISS]
- cellular response to retinoic acid [IMP]
- chemokine-mediated signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- integrin-mediated signaling pathway [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- long-term synaptic potentiation [ISS]
- marginal zone B cell differentiation [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone mineralization [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IMP]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of potassium ion transport [IDA]
- peptidyl-tyrosine autophosphorylation [IBA, ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of B cell chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of protein kinase activity [IMP]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- protein autophosphorylation [TAS]
- protein complex assembly [TAS]
- protein phosphorylation [TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of cell adhesion [IMP]
- regulation of cell shape [IMP]
- regulation of establishment of cell polarity [ISS]
- regulation of inositol trisphosphate biosynthetic process [ISS]
- regulation of macrophage chemotaxis [ISS]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of release of sequestered calcium ion into cytosol [ISS]
- response to stress [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- tumor necrosis factor-mediated signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- apical dendrite [ISS]
- cell body [ISS]
- cytoplasm [IDA]
- cytosol [TAS]
- dendrite [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA]
- growth cone [ISS]
- lamellipodium [IDA]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Homo sapiens
PREY
ARHGAP10
GRAF2, PS-GAP, PSGAP
Rho GTPase activating protein 10
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 170.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID