BAIT
PDK2
PDHK2, PDKII
pyruvate dehydrogenase kinase, isozyme 2
GO Process (14)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to nutrient [ISS]
- cellular response to reactive oxygen species [IMP]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [ISS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- protein phosphorylation [IDA, TAS]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [ISS, TAS]
- regulation of cellular ketone metabolic process [ISS]
- regulation of gluconeogenesis [ISS]
- regulation of glucose metabolic process [ISS]
- regulation of pH [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STIP1
HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
stress-induced phosphoprotein 1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 31.24324324 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID