BAIT
MYLK
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
myosin light chain kinase
GO Process (10)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- actin filament organization [IBA]
- aorta smooth muscle tissue morphogenesis [IMP]
- bleb assembly [IMP]
- cellular hypotonic response [IDA]
- muscle contraction [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of wound healing [IDA]
- smooth muscle contraction [IBA, ISS]
- tonic smooth muscle contraction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GDI2
HEL-S-46e, RABGDIB, RP11-318E3.2
GDP dissociation inhibitor 2
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 61.2 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID