BAIT
STK32C
PKE, YANK3, RP11-140A10.1
serine/threonine kinase 32C
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
HLA-A
HLAA, DAQB-90C11.16-002
major histocompatibility complex, class I, A
GO Process (17)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [IDA]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [IMP]
- immune response [IMP, NAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of memory T cell activation [IDA]
- protection from natural killer cell mediated cytotoxicity [IDA]
- regulation of defense response to virus by virus [TAS]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi apparatus [IDA, ISS]
- Golgi medial cisterna [IDA]
- Golgi membrane [TAS]
- MHC class I protein complex [IDA, ISS]
- cell surface [IDA, ISS]
- early endosome membrane [TAS]
- endoplasmic reticulum [IDA, ISS]
- endoplasmic reticulum exit site [IDA]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [NAS]
- membrane [IDA]
- phagocytic vesicle membrane [TAS]
- plasma membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 68.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID