BAIT
GSG2
HASPIN
germ cell associated 2 (haspin)
GO Process (6)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore [IMP]
- intracellular signal transduction [IDA]
- mitotic sister chromatid cohesion [IMP]
- protein localization to chromosome, centromeric region [IMP]
- protein phosphorylation [IDA]
- regulation of spindle checkpoint [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
PRNP
ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, RP5-1068H6.2
prion protein
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- axon guidance [TAS]
- cellular copper ion homeostasis [NAS]
- metabolic process [TAS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of activated T cell proliferation [ISS]
- negative regulation of calcineurin-NFAT signaling cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-2 production [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- response to oxidative stress [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 102.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID