BAIT
CDKL2
KKIAMRE, P56
cyclin-dependent kinase-like 2 (CDC2-related kinase)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PKP2
ARVD9
plakophilin 2
GO Process (20)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- adherens junction maintenance [ISS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cardiac muscle cell action potential [ISS]
- cardiac muscle cell action potential involved in contraction [IMP]
- cell communication by electrical coupling involved in cardiac conduction [ISS]
- cell-cell signaling involved in cardiac conduction [IMP]
- desmosome assembly [IMP]
- gap junction assembly [ISS]
- heart development [ISS]
- intermediate filament bundle assembly [IMP]
- lipid homeostasis [ISS]
- maintenance of organ identity [IMP]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of sodium ion transport [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of tight junction assembly [ISS]
- single organismal cell-cell adhesion [ISS, NAS]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 136.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID