BAIT
WNK3
PRKWNK3, RP3-390O13.2
WNK lysine deficient protein kinase 3
GO Process (13)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- intracellular signal transduction [ISS]
- negative regulation of apoptotic process [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of ion transmembrane transporter activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of rubidium ion transmembrane transporter activity [IDA]
- positive regulation of rubidium ion transport [IDA]
- positive regulation of sodium ion transmembrane transporter activity [IDA, IMP]
- positive regulation of sodium ion transport [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [ISS]
- regulation of ion homeostasis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EPS15
AF-1P, AF1P, MLLT5
epidermal growth factor receptor pathway substrate 15
GO Process (7)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 408.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID