TAOK3
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of JNK cascade [IDA]
- negative regulation of protein kinase activity [TAS]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, IMP]
Gene Ontology Molecular Function
TAOK1
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- MAPK cascade [IBA]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- execution phase of apoptosis [IDA]
- mitotic cell cycle [TAS]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein phosphorylation [NAS]
- regulation of cytoskeleton organization [ISS]
- spindle checkpoint [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Quantitative Score
- 10438.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TAOK3 TAOK1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3746268 |
Curated By
- BioGRID