BAIT
TAOK3
DPK, JIK, MAP3K18
TAO kinase 3
GO Process (11)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of JNK cascade [IDA]
- negative regulation of protein kinase activity [TAS]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
USP15
UNPH-2, UNPH4
ubiquitin specific peptidase 15
GO Process (9)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- histone H2B conserved C-terminal lysine deubiquitination [IDA]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 238.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID