BAIT
TAOK2
MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, UNQ2971/PRO7431
TAO kinase 2
GO Process (14)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- actin cytoskeleton organization [IDA]
- activation of MAPKK activity [IDA]
- apoptotic process [NAS]
- cell migration [NAS]
- cellular response to DNA damage stimulus [IDA]
- focal adhesion assembly [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein targeting to membrane [NAS]
- regulation of cell growth [NAS]
- regulation of cell shape [IDA]
- response to stress [IDA]
- stress-activated MAPK cascade [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDCD10
CCM3, TFAR15
programmed cell death 10
GO Process (20)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- establishment of Golgi localization [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IGI]
- negative regulation of apoptotic process [IDA]
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IMP]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of gene expression [IMP]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP]
- positive regulation of stress-activated MAPK cascade [IDA]
- protein stabilization [IMP]
- regulation of Rho protein signal transduction [IMP]
- response to hydrogen peroxide [IDA]
- stress fiber assembly [IMP]
- wound healing, spreading of cells [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 68.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID