AGTR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- Rho protein signal transduction [IDA]
- angiotensin-activated signaling pathway [IDA]
- calcium-mediated signaling [IDA]
- cell chemotaxis [IDA]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IPI]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol esterification [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of phospholipase A2 activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- regulation of blood vessel size by renin-angiotensin [IC]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of inflammatory response [IC]
- regulation of renal sodium excretion [NAS]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC]
- regulation of vasoconstriction [IC, IDA, NAS]
- regulation of vasodilation [IC]
- renin-angiotensin regulation of aldosterone production [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization.
The human angiotensin II type 1 receptor (AT?R) is a member of the G protein-coupled receptor (GPCR) superfamily and represents an important target for cardiovascular therapeutic intervention. Agonist-activation of the AT?R induces ?-arrestin-dependent endocytosis to early endosomes in which the receptor resides as a protein complex with the Rab GTPase Rab5. In the present study, we examined whether other Rab ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID