PCGF3
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PCGF6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells.
Polycomb group proteins assemble into multi-protein complexes, known as Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), that guide cell fate decisions during embryonic development. PRC1 forms an array of biochemically distinct canonical PRC1 (cPRC1) or non-canonical PRC1 (ncPRC1) complexes characterized by the mutually exclusive presence of PCGF (PCGF1-PCGF6) paralog subunit; however, whether each one of these subcomplexes fulfills ... [more]
Throughput
- Low Throughput
Ontology Terms
- stem cell proliferation (GO:0072089)
Additional Notes
- CRISPR method
- deletion of pcgf1/2/3/4/5 combined with conditional removal of pcgf6 resulted in decreased ESC proliferation combined with loss of pluripotency markers and differentiated morphology
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PCGF3 PCGF6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 44.1463 | BioGRID | 2942987 |
Curated By
- BioGRID