BAIT
TIPARP
ARTD14, PARP7, pART14
TCDD-inducible poly(ADP-ribose) polymerase
GO Process (3)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
KIF2A
CDCBM3, HK2, KIF2
kinesin heavy chain member 2A
GO Process (9)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- metabolic process [IBA, TAS]
- microtubule depolymerization [IBA]
- microtubule-based movement [IBA, TAS]
- mitotic cell cycle [TAS]
- mitotic spindle organization [IDA]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor.
Inhibitors directed toward PARP1 and PARP2 are approved agents for the treatment of BRCA1 and BRCA2-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and other diseases. Recently, an inhibitor of PARP7 (RBN-2397) has reached early-stage human clinical trials. Here, we performed a genome-wide CRISPR screen ... [more]
Mol Cancer Ther Jul. 05, 2022; 21(7);1076-1089 [Pubmed: 35439318]
Throughput
- High Throughput
Curated By
- BioGRID