BAIT
NTRK3
TRKC, gp145(trkC)
neurotrophic tyrosine kinase, receptor, type 3
GO Process (12)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- activation of Ras GTPase activity [IDA]
- activation of protein kinase B activity [IDA]
- negative regulation of protein phosphorylation [IDA]
- neurotrophin signaling pathway [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNAJC10
ERdj5, JPDI, MTHr, PDIA19, UNQ495/PRO1012
DnaJ (Hsp40) homolog, subfamily C, member 10
GO Process (6)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of protein phosphorylation [IDA]
- positive regulation of ATPase activity [ISS]
- protein folding in endoplasmic reticulum [IDA]
- response to endoplasmic reticulum stress [IDA]
Gene Ontology Molecular Function- ATPase activator activity [ISS]
- ATPase binding [IPI]
- Hsp70 protein binding [IPI]
- chaperone binding [IDA]
- disulfide oxidoreductase activity [ISS]
- misfolded protein binding [IDA]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [ISS]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISS]
- ATPase activator activity [ISS]
- ATPase binding [IPI]
- Hsp70 protein binding [IPI]
- chaperone binding [IDA]
- disulfide oxidoreductase activity [ISS]
- misfolded protein binding [IDA]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [ISS]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID