BAIT
NTRK3
TRKC, gp145(trkC)
neurotrophic tyrosine kinase, receptor, type 3
GO Process (12)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- activation of Ras GTPase activity [IDA]
- activation of protein kinase B activity [IDA]
- negative regulation of protein phosphorylation [IDA]
- neurotrophin signaling pathway [IDA]
- positive regulation of actin cytoskeleton reorganization [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCFD1
C14orf163, RA410, SLY1, SLY1P, STXBP1L2, FKSG23
sec1 family domain containing 1
GO Process (8)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cell morphogenesis [ISS]
- negative regulation of autophagic vacuole assembly [IMP]
- phagocytosis [ISS]
- post-Golgi vesicle-mediated transport [ISS]
- regulation of ER to Golgi vesicle-mediated transport [ISS]
- regulation of protein transport [IMP]
- response to toxic substance [IEP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID