BAIT
ROR2
BDB, BDB1, NTRKR2, RP11-8I8.2
receptor tyrosine kinase-like orphan receptor 2
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HMGA2
BABL, HMGI-C, HMGIC, LIPO, STQTL9
high mobility group AT-hook 2
GO Process (42)
GO Function (19)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA damage response, detection of DNA damage [IDA]
- base-excision repair [IDA]
- chondrocyte differentiation [IDA]
- chondrocyte proliferation [IDA]
- chromatin organization [TAS]
- chromosome breakage [IDA]
- endodermal cell differentiation [IMP]
- epithelial to mesenchymal transition [IMP]
- fat cell differentiation [IMP]
- heterochromatin assembly [IDA]
- histone H2A-S139 phosphorylation [IDA]
- mesenchymal cell differentiation [IMP]
- mesodermal cell differentiation [IMP]
- mesodermal-endodermal cell signaling [IMP]
- mitotic G2 DNA damage checkpoint [IDA]
- multicellular organismal development [TAS]
- negative regulation by host of viral transcription [IDA]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of double-strand break repair via nonhomologous end joining [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- oncogene-induced cell senescence [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular response to X-ray [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of response to DNA damage stimulus [IDA]
- positive regulation of stem cell proliferation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of cell cycle process [IDA]
- regulation of cellular response to drug [IDA]
- regulation of stem cell maintenance [IMP, TAS]
- regulation of transcription, DNA-templated [IMP]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- stem cell differentiation [IEP]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [IDA, IMP]
- C2H2 zinc finger domain binding [IMP]
- DNA binding [NAS]
- DNA binding, bending [IDA, IMP]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- DNA-dependent protein kinase activity [IDA]
- MH1 domain binding [IDA]
- MH2 domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- cAMP response element binding [IDA]
- core promoter binding [IDA]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- regulatory region DNA binding [IDA]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.0 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID