BAIT
FGFR4
CD334, JTK2, TKF
fibroblast growth factor receptor 4
GO Process (21)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphate ion homeostasis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of proteolysis [IMP]
- protein autophosphorylation [IDA]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of extracellular matrix disassembly [IMP]
- regulation of lipid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PAK2
PAK65, PAKgamma
p21 protein (Cdc42/Rac)-activated kinase 2
GO Process (24)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA]
- negative regulation of protein kinase activity [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of apoptotic process [TAS]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- signal transduction by phosphorylation [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.02 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Curated By
- BioGRID