BAIT
FGFR4
CD334, JTK2, TKF
fibroblast growth factor receptor 4
GO Process (21)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell migration [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphate ion homeostasis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of proteolysis [IMP]
- protein autophosphorylation [IDA]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of extracellular matrix disassembly [IMP]
- regulation of lipid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FGF2
BFGF, FGF-2, FGFB, HBGF-2
fibroblast growth factor 2 (basic)
GO Process (40)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physical and functional interactome atlas of human receptor tyrosine kinases.
Much cell-to-cell communication is facilitated by cell surface receptor tyrosine kinases (RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response to stimuli such as growth factors. Despite their central roles, the functions of many RTKs are still poorly understood. To resolve the lack of systematic knowledge, we apply three complementary methods to map the molecular context and substrate profiles ... [more]
EMBO Rep Jun. 07, 2022; 23(6);e54041 [Pubmed: 35384245]
Quantitative Score
- 0.01 [BFDR Score]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein interactors with a BFDR of less than or equal to 0.05 (BFDR score reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGFR4 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9489 | BioGRID | 3549876 |
Curated By
- BioGRID