BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RAD50
Mrell, Rad50l, RP23-239O19.3
RAD50 homolog (S. cerevisiae)
GO Process (13)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA duplex unwinding [ISO]
- DNA recombination [ISO]
- DNA repair [ISO]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [ISO]
- negative regulation of viral entry into host cell [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- positive regulation of kinase activity [ISO]
- positive regulation of protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of mitotic recombination [ISO]
- telomere maintenance via telomerase [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID