BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
FKBP8
38kDa, FKBP-38, FKBP-8, Fkbp38
FK506 binding protein 8
GO Process (13)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- camera-type eye development [IMP]
- cell fate specification [IMP]
- chaperone-mediated protein folding [IBA]
- dorsal/ventral neural tube patterning [IDA, IGI, IMP]
- dorsal/ventral pattern formation [IMP]
- multicellular organism growth [IGI]
- negative regulation of apoptotic process [IMP]
- neural tube development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of BMP signaling pathway [IGI]
- regulation of gene expression [IGI]
- smoothened signaling pathway [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID