BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GNA13
AU024132, AU043124, Galpha13, RP23-465A12.1
guanine nucleotide binding protein, alpha 13
GO Process (15)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISA, ISO, TAS]
- GTP catabolic process [IBA]
- Rho protein signal transduction [IDA]
- activation of phospholipase D activity [IBA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IGI]
- angiogenesis [IMP]
- cell differentiation [IDA]
- in utero embryonic development [IGI]
- intracellular signal transduction [IDA]
- patterning of blood vessels [IMP]
- platelet activation [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of cell migration [IMP]
- regulation of cell shape [IDA]
- signal transduction [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID