BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HSPA8
2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10
heat shock protein 8
GO Process (10)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IGI, ISO]
- chaperone-mediated protein folding [ISO]
- clathrin coat disassembly [IGI]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein folding [IDA]
- protein refolding [ISO]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- ubiquitin ligase complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID