BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DNAJA1
Hsj2, Nedd7, RP23-135L5.1
DnaJ (Hsp40) homolog, subfamily A, member 1
GO Process (12)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [ISO]
- androgen receptor signaling pathway [IMP]
- negative regulation of JUN kinase activity [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of protein ubiquitination [ISO]
- positive regulation of apoptotic process [ISO]
- protein localization to mitochondrion [ISO]
- protein refolding [IBA]
- regulation of protein transport [ISO]
- sperm motility [IMP]
- spermatogenesis [IMP]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID