BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PHGDH
3-PGDH, 3PGDH, 4930479N23, A10, PGAD, PGD, PGDH, SERA
3-phosphoglycerate dehydrogenase
GO Process (14)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G1 to G0 transition [IMP]
- L-serine metabolic process [IMP]
- gamma-aminobutyric acid metabolic process [IMP]
- glial cell development [IMP]
- glutamine metabolic process [IMP]
- glycine metabolic process [IMP]
- neural tube development [IMP]
- neurogenesis [IMP]
- neuron projection development [IMP]
- oxidation-reduction process [ISO]
- regulation of gene expression [IMP]
- spinal cord development [IMP]
- taurine metabolic process [IMP]
- threonine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID