BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HADHA
C77020, Mtpa
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
GO Process (4)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
- 3-hydroxyacyl-CoA dehydrogenase activity [ISO]
- NAD binding [ISO]
- acetyl-CoA C-acyltransferase activity [ISO]
- enoyl-CoA hydratase activity [ISO, TAS]
- fatty-acyl-CoA binding [ISO]
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity [IDA, ISO]
- long-chain-enoyl-CoA hydratase activity [ISO]
- protein complex binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID