BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
AFG3L2
2310036I02Rik, AW260507, Emv66, par
AFG3-like AAA ATPase 2
GO Process (12)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- axonogenesis [IMP]
- cristae formation [IGI]
- death [IMP]
- mitochondrial fusion [IGI]
- mitochondrial protein processing [IGI]
- mitochondrion organization [IGI]
- muscle fiber development [IMP]
- myelination [IMP]
- nerve development [IMP]
- neuromuscular junction development [IMP]
- regulation of multicellular organism growth [IMP]
- righting reflex [IMP]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID