BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
STOML2
0610038F01Rik, MSLP2, SLP-2, RP23-124L1.8
stomatin (Epb7.2)-like 2
GO Process (15)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [IMP]
- T cell receptor signaling pathway [ISO]
- cellular calcium ion homeostasis [ISO]
- interleukin-2 production [IMP]
- lipid localization [IMP]
- mitochondrial ATP synthesis coupled proton transport [IMP, ISO]
- mitochondrial calcium ion transport [ISO]
- mitochondrial protein processing [IMP]
- mitochondrion localization [IMP]
- mitochondrion organization [ISO]
- positive regulation of cardiolipin metabolic process [ISO]
- positive regulation of mitochondrial DNA replication [ISO]
- positive regulation of mitochondrial membrane potential [ISO]
- protein oligomerization [ISO]
- stress-induced mitochondrial fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- T cell receptor complex [ISO]
- actin cytoskeleton [ISO]
- cell [IMP]
- extrinsic component of plasma membrane [IDA, ISO]
- immunological synapse [ISO]
- intracellular [IMP]
- membrane raft [ISO]
- mitochondrial inner membrane [IDA, ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID