BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DNAJB2
2700059H22Rik, Dnajb10, Hsj1, mDj8
DnaJ (Hsp40) homolog, subfamily B, member 2
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of inclusion body assembly [ISO]
- negative regulation of protein deubiquitination [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein refolding [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ALS-linked loss of Cyclin-F function affects HSP90.
The founding member of the F-box protein family, Cyclin-F, serves as a substrate adaptor for the E3 ligase Skp1-Cul1-F-box (SCF)<sup>Cyclin-F</sup> which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in <i>CCNF</i> encoding for Cyclin-F are associated with amyotrophic lateral sclerosis (ALS). However, it remains elusive whether <i>CCNF</i> mutations affect the ... [more]
Life Sci Alliance Sep. 16, 2022; 5(12); [Pubmed: 36114006]
Throughput
- High Throughput
Curated By
- BioGRID